Solvents can have a direct effect on the skin and be absorbed through the skin.
Most solvents will dissolve the natural oils in the skin and cause dryness and chapping. Some solvents are also directly irritating to the skin or cause severe skin allergies in some people. Regular or constant immersing or cleaning bare hands with solvents will cause skin dermatitis.
Organic solvents are among the most frequently used substance in industry. Repeated skin contact leads to excessive dehydration of surface keratin and eczema. In this worker, who habitually used an organic solvent for cleansing purposes, the dermatitis appears as scattered, coin shaped concentrated patches, commonly referred to as “nummular” eczema.
Skin absorption of solvents
A group of solvents known as “glycol ethers” and certain alcohol solvents are especially absorbable through the skin and cause internal health effects